A novel method for installing sulfur into complex molecules

A group of highly reactive compounds called persulfides have provoked great curiosity among biochemists, because of their role in nature, and how they interact with proteins to change their structure and function, affecting ...

Expanding the genetic code with quadruplet codons

One of modern biologists' most ambitious goals is to learn how to expand or otherwise modify the genetic code of life on Earth, in order to make new, artificial life forms. Part of the motivation for this "synthetic biology" ...

A major addition to chemists' toolkit for building new molecules

Chemists at Scripps Research have solved a long-standing problem in their field by developing a method for making a highly useful and previously very challenging type of modification to organic molecules. The breakthrough ...

Force-sensing PIEZO proteins are at work in plants, too

A family of proteins that sense mechanical force—and enable our sense of touch and many other important bodily functions—also are essential for proper root growth in some plants, according to a study led by scientists ...

Experimental vaccine blunts the deadliest of synthetic opioids

As the opioid epidemic raged on with an even greater force during COVID-19, the Scripps Research laboratory of chemist Kim Janda, Ph.D., has been working on new therapeutic interventions that may be able to prevent the bulk ...

Undruggable diseases gain a new RNA drug-discovery tool

Imagine trying to throw a bullseye when the dartboard lies buried within a crumpled box. That's the challenge faced by scientists working to make new medicines for some 'undruggable' diseases, including a type of metastatic ...

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