Dynamic twists and loops can enable DNA to modulate its function

When people think of DNA, they visualize a string-like double helix structure. In reality, the DNA double helix in cells is supercoiled and constrained into loops. This supercoiling and looping are known to influence every ...

New insights into how KLF4 influences gene expression

A team led by researchers at Baylor College of Medicine has discovered a mechanism by which transcription factor KLF4 can help to organize chromatin, thus influencing gene expression.

Biologists construct a 'periodic table' for cell nuclei

One hundred fifty years ago, Dmitri Mendeleev created the periodic table, a system for classifying atoms based on the properties of their nuclei. This week, a team of biologists studying the tree of life has unveiled a new ...

Novel guidelines help select optimal deconvolution method

Biomedical scientists are increasingly using deconvolution methods, those used to computationally analyze the composition of complex mixtures of cells. One of their challenges is to select one method that is appropriate for ...

3-D printed Biomesh minimizes hernia repair complications

Hernias are one of the most common soft tissue injuries. Hernias form when intra-abdominal content, such as a loop of the intestine, squeezes through weak, defective or injured areas of the abdominal wall.

Revealing the unexpected structure of iron-exporter ferroportin

Too much or too little iron in the body can lead to disease but organisms have developed ways to keep iron levels in balance. Ferroportin, the only known iron exporter that releases iron into the blood stream, is a crucial ...

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