What organizes the genome in the nucleus?

Spatial separation of active from inactive fractions of the genome in the cell nucleus is crucial for gene expression control. A new study uncovers leading mechanisms of such separation and turns our picture of the nucleus ...

Keeping chromosomes in check: A new role for heterochromatin

Although many people are aware that chromosomal damage and shortening contribute to the aging process, understanding how chromosomal defects occur is about more than just finding a way to turn back the clock. Large changes ...

The nanoscopic structure that locks up our genes

For decades, scientists could only speculate about the shape of heterochromatin, a type of chromatin that consists of tightly packed DNA and proteins. Recently, however, researchers from the Okinawa Institute of Science and ...

Histone 1, the guardian of genome stability

Scientists headed by Ferran Azorín at the Institute for Research in Biomedicine (IRB Barcelona) have discovered why histone 1 is a major protection factor against genomic instability and a vital protein. Their study of the ...

Researchers find new mechanism for genome regulation

The same mechanisms that quickly separate mixtures of oil and water are at play when controlling the organization in an unusual part of our DNA called heterochromatin, according to a new study by researchers at the Department ...

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