Picrotoxinin, a plant-derived toxin that Asian fishermen traditionally have used to paralyze and catch fish, has long been seen as a possible starting point for new human therapeutics and other neuroactive products.
Biochemistry
Dec 21, 2023
0
3
Existing flu vaccines provide only limited, seasonal protection because they target highly changeable proteins on the virus. Scripps Research scientists have now designed a vaccine that should work broadly against influenza ...
Bio & Medicine
Dec 8, 2023
0
51
Searching for new ways to block the growth of cancer cells is like looking for a needle in a haystack. Tumor cells rely on thousands of proteins to function, but only a few of those proteins can be precisely targeted by drugs ...
Biochemistry
Oct 5, 2023
0
76
Scripps Research chemists have extended a powerful molecule-building method—called C-H activation—to the broad class of chemicals known as alcohols.
Biochemistry
Sep 6, 2023
0
130
The ability to sense mechanical stimuli, like touch or blood pressure, is essential to physiological processes in humans and across the animal kingdom. In a new study, Scripps Research scientists show how the sensory ion ...
Cell & Microbiology
Aug 16, 2023
0
497
Often referred to as the "powerhouses of the cell," mitochondria are well known for their role as energy suppliers, but these organelles are also critical for maintaining our overall health. Mitochondrial stress is associated ...
Molecular & Computational biology
Aug 7, 2023
0
106
A new "molecular editing" technique from Scripps Research enables chemists to add new elements to organic molecules at locations that were previously out of reach.
Analytical Chemistry
May 31, 2023
0
14
Scripps Research chemists have solved a long-standing problem in the field of pharmaceutical chemistry with a relatively simple and controllable method for making benzocyclobutenes (BCBs)—a class of reactive compounds that ...
Analytical Chemistry
May 11, 2023
0
38
Scripps Research scientists have developed a new strategy for identifying small molecules that can change the function of proteins, offering a promising path for discovering targeted drugs. In collaboration with scientists ...
Biochemistry
Apr 27, 2023
0
54
Two prominent origin-of-life chemists have published a new hypothesis for how the first sugars—which were necessary for life to evolve—arose on the early Earth.
Biochemistry
Apr 13, 2023
0
83
