Researchers define role of Tmem231 in maintaining ciliary function

Researchers reveal how a protein linked to Meckel syndrome (MKS) and other human diseases regulates the membrane composition of cilia, finger-like projections on the surface of cells that communicate signals. The study appears ...

Sall4 is required for DNA repair in stem cells

A protein that helps embryonic stem cells (ESCs) retain their identity also promotes DNA repair, according to a study in The Journal of Cell Biology. The findings raise the possibility that the protein, Sall4, performs a ...

Desmoplakin's tail gets the message

Cells control the adhesion protein desmoplakin by modifying the tail end of the protein, and this process goes awry in some patients with arrhythmogenic cardiomyopathy, according to a study in The Journal of Cell Biology.

Cells take sole responsibility for Merkel cell maintenance

Researchers have identified a population of "progenitor" cells in the skin that are solely responsible for the generation and maintenance of touch-sensing Merkel cells. The study appears in The Journal of Cell Biology.

M6P deficiency leaves B cells out of sorts

A group of white blood cells known as B cells, which play a key role in the human immune response, need a protein-targeting signal called mannose 6-phosphate (M6P) in order to proliferate, differentiate, and present immune ...

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