Biomolecular sliding at the nanoscale

In organisms whose cells have a nucleus, like plants and animals, the basic packaging units of DNA are the so-called nucleosomes. A nucleosome consists of a segment of DNA wound around eight proteins known as histones. Gene ...

Locking and unlocking molecular structures on demand

Researchers at Kanazawa University report in Angewandte Chemie International Edition how the formation and deformation speed of interlocked molecular structures called rotaxanes can be tuned—a discovery that may lead to ...

Nanoscopic tool assesses alternative COVID-19 prevention

Researchers at Kanazawa University report in Nano Letters how high-speed atomic force microscopy can be used to assess the effectivity of spike-neutralizing antibodies for preventing COVID-19. The use of such antibodies offers ...

The offshoot of cells visualized in real time

In a study recently published in the Journal of Extracellular Vesicles, researchers from Kanazawa University use high-speed microscopy to capture the dynamics of nanosized sacs released from cells.

Biological lasso: Enhanced drug delivery to brain

In a study recently published in the journal Nature Biomedical Engineering, researchers from Kanazawa University use a method called "lasso-grafting" to design therapeutics with enhanced longevity and brain penetration.

Chemists uncover cracks in the armor of cellulose nanocrystals

Chemists in Japan, Canada and Europe have uncovered flaws in the surface structure of cellulose nanocrystals—an important step toward deconstructing cellulose to produce renewable nano-materials relevant to biochemical ...

Simulating 3D-AFM images for systems not in equilibrium

Researchers at Kanazawa University report in the Journal of Physical Chemistry Letters how to simulate 3D atomic force microscopy images of out-of-equilibrium systems involving biomolecules. The approach makes use of a celebrated ...

Revealing atomistic structures behind AFM imaging

Atomic force microscopy (AFM) allows us to visualize the dynamics of single biomolecules during their functional activity. All observations are, however, restricted to regions accessible by a fairly big probing tip during ...

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