Pancreatic cancer discovery reveals how the aggressive cancer fuels its growth

Pancreatic cancer discovery reveals how the aggressive cancer fuels its growth
The new discovery represents the fulfillment of years of work for David F. Kashatus, Ph.D., who first proposed the research project while interviewing at UVA in 2012. Credit: Dan Addison/UVA

A new discovery about pancreatic cancer sheds light on how the cancer fuels its growth and may help explain how promising cancer drugs work—and for whom they will fail.

The finding one day could help doctors determine which treatments will be most effective for patients, so that they get the best outcomes.

"Pancreatic cancer is a very difficult problem. It has been a very difficult problem for a long time. The survival for pancreatic cancer patients is very low compared to other tumors," said researcher David F. Kashatus, Ph.D., of the University of Virginia School of Medicine and the UVA Cancer Center. "We're really trying to understand the biology so that scientists and developers can be more informed as they try to tackle this disease. Any progress we can make, no matter how small, is going to be an improvement over the current state of affairs."

A Big Mystery of Pancreatic Cancer

The new discovery represents the fulfillment of years of work for Kashatus, who first proposed the research project while interviewing at UVA in 2012. It also helps to answer an 80-year-old mystery: Why and how do cancers rewire cells to fuel themselves using a much more inefficient process?

Pancreatic cancer discovery reveals how the aggressive cancer fuels its growth
"We're really trying to understand the biology so that scientists and drug developers can be more informed as they try to tackle this disease," said UVA's David F. Kashatus, PhD. "Any progress we can make, no matter how small, is going to be an improvement over the current state of affairs." Credit: Dan Addison/UVA

Scientists previously have noted strange changes in the shape of mitochondria, the powerhouses of cells, in cancers driven by mutations in the RAS gene. Kashatus wanted to understand what was occurring and how it affected 's growth.

Kashatus found that when the mutated RAS gene gets activated, it causes the mitochondria to fragment. This fragmentation supports the earliest shifts toward the cancer's new fueling process. This was quite surprising, because suddenly the mitochondria were playing a very unusual role. Their division was actually helping the cancer establish itself.

But there's good news: This process could prove to be a weakness for the cancer that doctors could exploit to help patients. Kashatus found that blocking mitochondrial division in tumor samples largely prevented the tumors from growing. And when they did grow, the gradually lost . This was bad for the cancer, and the loss of mitochondria represents another weakness doctors could exploit.

"This is really playing two distinct roles: On the one hand, it's promoting this shift in metabolism. But it's also promoting mitochondrial health," Kashatus said. "These two things are combining to drive the pancreatic tumor growth process. So I think this is something that could be therapeutically valuable. But it also really teaches us about tumor growth in general."

Explaining How Cancer Drugs Work

The finding also may help explain the workings of several drugs in development, and it could help doctors understand which patients they will benefit, said Kashatus, of UVA's Department of Microbiology, Immunology and Cancer Biology.

"Inhibiting [mitochondrial division in patients' cells] would be a nice future goal for us. However, the drugs targeting this process are really very early in development, and so it's not something that will really be ready for the clinic anytime soon," he said. "But this work can really help us understand how some of these other drugs that are a little bit further along in the process may be acting, so that we can better understand which patients may or may not benefit."

More information: Sarbajeet Nagdas et al, Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth, Cell Reports (2019). DOI: 10.1016/j.celrep.2019.07.031

Journal information: Cell Reports
Citation: Pancreatic cancer discovery reveals how the aggressive cancer fuels its growth (2019, September 26) retrieved 28 March 2024 from https://medicalxpress.com/news/2019-09-pancreatic-cancer-discovery-reveals-aggressive.html
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