Specific changes to non-coding RNA may be part of what makes us human

Human-specific variants of four microRNAs may have altered expression levels and gene targets compared to other great apes, according to a study published April 22, 2016 in the open-access journal PLOS ONE by Alicia Gallego from the Institute of Evolutionary Biology, Spain, and colleagues.

MicroRNAs are post-transcriptional gene regulators known to be involved in almost every biological function. They are highly conserved among species and, while some differences exist, the effect of the variations is often unclear. The authors of the present study analysed over 1500 microRNAs to identify variations between humans and other great ape species, including orangutans, gorillas, bonobos and chimpanzees, and the possible effect of these variations on function.

The authors found that changes in the sequence and length of four microRNAs may be specific to humans. Two were highly expressed in brain tissue and may exert effects on genes with neural functions, while two exhibit restricted expression patterns that the authors posited implied a role in development. The authors also found that "age" might matter; in an evolutionary sense, "younger" microRNAs had less sequence conservation, expression and disease association, and were more isolated than "older" microRNAs.

The authors suggest this study may aid in our understanding of how non-coding elements may have played a role in shaping some traits that ultimately became human-specific. They also hope that it provides a framework to study the possible impact of these changes on recent human evolution.