Systems biology met epigenetics two decades ago and the model did not require computation. It required a common sense approach to nutrient chemical-dependent individual survival and pheromone-controlled reproduction.

Human Pheromones: Epigenetic Effects of Odors and Their Affects on Behavior
http://f1000.com/.../1092760

This model of systems biology represents the conservation of bottom-up organization and top-down activation via:
1.Nutrient-dependent stress-induced and social stress-induced intracellular changes in the homeostatic balance of microRNA(miRNA) and messenger RNA (mRNA);
2.Intermolecular changes in DNA (genes);
3.Non-random experience-dependent stochastic variations in de novo gene expression for odor receptors;
4.The required gene-cell-tissue-organ-organ system pathway that links sensory input directly to gene activation in neurosecretory cells of the brain;
5.The required reciprocity that links gene expression to behavior that alters gene expression