Study reveals how some bacterial infections become chronic

In the early 1900s, a cook named Mary Mallon, better known as "Typhoid Mary," spread Salmonella Typhi, the causative agent of typhoid fever, to dozens of her patrons even though she showed no symptoms. Many people today harbor ...

Video: Single cells have their own defenses against pathogens

In the fight against pathogens, most researchers have focused on the diverse immune system arsenal that protects people against infection. However, the lab of Yale microbiologist Jorge Galan explored an evolutionarily ancient ...

Typhoid fever toxin has a sweet tooth

Although the insidious bacterium Salmonella typhi has been around for centuries, very little is actually known about its molecular mechanisms. A new study from researchers at the College of Veterinary Medicine addresses this ...

Molecular switch lets salmonella fight or evade immune system

Researchers at the University of Illinois at Chicago have discovered a molecular regulator that allows salmonella bacteria to switch from actively causing disease to lurking in a chronic but asymptomatic state called a biofilm.

Typhoid Mary case may be cracked, a century later

When Typhoid Mary died in 1938, in medical exile on a tiny New York island, she took untold numbers of Salmonella typhi to her grave. No one knew how the bacteria managed to thrive and not kill her.

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