Cell membrane protrusions called blebs that typically signify the end of life for healthy cells do the opposite for melanoma cells, activating processes in these cells that help them to survive and spread, a UT Southwestern ...
Cell & Microbiology
Mar 6, 2023
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11
Researchers from Bochum and Osnabrück have gained new insights into the structure of the Ras protein, which acts as a molecular switch for cell growth and is involved in the development of cancer. With the help of fluorescence ...
Biotechnology
Jun 2, 2021
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7
Many cancer medications fail to effectively target the most commonly mutated cancer genes in humans, called RAS. Now, Salk Professor Geoffrey Wahl and a team of scientists have uncovered details into how normal RAS interacts ...
Cell & Microbiology
May 19, 2020
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48
Ras proteins are molecular switches that decide if and when cells divide inside our bodies. An impairment of their function may result in the formation of a tumour. The process of switching the proteins on and off has been ...
Biochemistry
Mar 21, 2018
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6
For several years, scientists have known that SIRT6 – one of seven sirtuins, a family of mammalian proteins with important biological functions, including promoting longer, healthier life – is a tumor suppressor. It has ...
Biochemistry
May 11, 2017
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4
Using subatomic resolution, researchers have gained insights into the dynamic modus operandi of two switch proteins which are responsible for the import of compounds into the nucleus and for cell growth. The team headed by ...
Biochemistry
Oct 6, 2015
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10
A breakthrough discovery into how living cells process and respond to chemical information could help advance the development of treatments for a large number of cancers and other cellular disorders that have been resistant ...
Biochemistry
Jul 3, 2014
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0
Supercomputer simulations have shown that clusters of a protein linked to cancer warp cell membranes, according to scientists at The University of Texas Health Science Center at Houston (UTHealth) Medical School. This research ...
Biochemistry
Jun 23, 2014
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0
German biophysicists at Ruhr-Universitaet-Bochum in collaboration with the MPI Dortmund have for the first time measured the orientation of the Ras protein bound to the cell membrane.
Biochemistry
Oct 15, 2012
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0
Proteins accelerate certain chemical reactions in cells by several orders of magnitude. The molecular mechanism by which the Ras protein accelerates the cleavage of the molecule GTP and thus slows cell growth is described ...
Biochemistry
Sep 18, 2012
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