How 'extracellular chaperones' help remove abnormal proteins

Proteins tend to fold wrongly and become defective when exposed to stressors such as heat, oxidation, and pH changes. Accumulation of abnormal proteins contributes to neurodegenerative diseases like Alzheimer's.

How protein aggregation occurs in cells

Published in the Molecular Cell journal on July 19, a research study out of the Hatters Laboratory showed inappropriate protein aggregation is linked to poor outcomes for cell health and survival—especially in neurons in ...

Researchers deepen understanding of cellular stress responses

Chronic stress caused by changing temperatures, Alzheimer's disease or other diseases and forces is an unavoidable part of life. At the cellular level, the "first responders" to stress are known as molecular chaperones. Yet ...

Protein can release trapped histones in the cell

In the cell nucleus, histones play a crucial role packaging DNA into chromatin. Histones are however very sticky to both DNA and RNA, so to ensure they are transported to the cell nucleus after synthesis and bind to the right ...

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