Constructing a deep generative approach for functional RNA design

A collaborative research effort by Professor Hirohide Saito in the Department of Life Science Frontiers, CiRA, Kyoto University, and Professor Michiaki Hamada of Waseda University has developed the world's first deep generative ...

Chinese scientists unravel cGNAT2 role in cyanobacteria

Cyanobacteria are a diverse group of gram-negative bacteria that conduct plant-like oxygenic photosynthesis and are thought to be the evolutionary ancestors of chloroplasts in higher plants. Lysine acetylation is an important ...

Blue light: An on-off switch for enzymes

Light affects living organisms in many different ways, for example, plants orient their growth direction towards the sun, while circadian rhythms in humans are controlled by daylight. These processes always involve photoreceptors, ...

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Enzyme catalysis

Enzyme catalysis is the catalysis of chemical reactions by specialized proteins known as enzymes. Catalysis of biochemical reactions in the cell is vital due to the very low reaction rates of the uncatalysed reactions.

The mechanism of enzyme catalysis is similar in principle to other types of chemical catalysis. By providing an alternative reaction route and by stabilizing intermediates the enzyme reduces the energy required to reach the highest energy transition state of the reaction. The reduction of activation energy (ΔG) increases the number of reactant molecules with enough energy to reach the activation energy and form the product.

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