Biomolecular engineers at Rice University have found a C-worthy technique that dramatically enhances the accuracy of gene editing.
Molecular & Computational biology
Jul 15, 2020
0
108
Chinese scientists have found that cytosine base editors (BE3 and HF1-BE3) induce genome wide off-target mutations.
Biotechnology
Feb 28, 2019
0
101
Early life forms on Earth are likely to have mutated and evolved at much higher rates than they do today, suggests a new analysis from researchers at the University of North Carolina.
Biochemistry
Jul 6, 2016
11
61
An artificial base that enhances the protein-binding affinity and selectivity of DNA expands the DNA machinery.DNA aptamers are expected to play an important role in the diagnosis and treatment of various cancers and other ...
Biochemistry
Jul 19, 2013
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0
(Phys.org) —Adventitious changes in cellular DNA can endanger the whole organism, as they may lead to life-threatening illnesses like cancer. Researchers at LMU now report how byproducts of respiration cause mispairing ...
Biochemistry
May 22, 2013
0
0
(Phys.org) —Changes in the bases that make up DNA act as markers, telling a cell which genes it should read and which it shouldn't. In the journal Angewandte Chemie, a British team has now introduced a new method that makes ...
Biochemistry
Apr 25, 2013
0
0
Researchers from Huntsman Cancer Institute (HCI) at the University of Utah have developed a novel and powerful technique to identify the targets for a group of enzymes called RNA cytosine methyltransferases (RMTs) in human ...
Biotechnology
Apr 22, 2013
0
0
Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University have created more than 100 three-dimensional (3D) nanostructures using DNA building blocks that function like Lego® bricks—a ...
Bio & Medicine
Nov 29, 2012
5
0
Popularly dubbed "the book of life," the human genome is extraordinarily difficult to read. But without full knowledge of its grammar and syntax, the genome's 2.9 billion base-pairs of adenine and thymine, cytosine and guanine ...
Biotechnology
Jul 1, 2012
0
0
Imagine reading an entire book, but then realizing that your glasses did not allow you to distinguish "g" from "q." What details did you miss? Geneticists faced a similar problem with the recent discovery of a "sixth nucleotide" ...
Cell & Microbiology
May 17, 2012
2
0
Cytosine (C) is one of the four main bases found in DNA and RNA, along with adenine, guanine, and thymine (uracil in RNA). It is a pyrimidine derivative, with a heterocyclic aromatic ring and two substituents attached (an amine group at position 4 and a keto group at position 2). The nucleoside of cytosine is cytidine. In Watson-Crick base pairing, it forms three hydrogen bonds with guanine.
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