Researchers clock DNA's recovery time after chemotherapy

In the time it takes for an Amazon Prime delivery to arrive, cells damaged by chemotherapy can almost completely fix their most important DNA. That is the case in the livers of mice at least, according to a new study.

Team uses nanoparticles to enhance chemotherapy

(Phys.org) —University of Georgia researchers have developed a new formulation of cisplatin, a common chemotherapy drug, that significantly increases the drug's ability to target and destroy cancerous cells.

Fine tuning an old-school chemotherapy drug

First approved by the FDA in the 1970s, the chemotherapy drug cisplatin and its relative carboplatin remain mainstays of treatment for lung, head and neck, testicular and ovarian cancer. However, cisplatin's use is limited ...

Imaging metals within cells: Identifying the proteins that bind

(Phys.org)—Metals such as copper, zinc, and iron are important nutrients to all life. The special properties of these elements that make them so useful in technologies including batteries and catalysts – for example, ...

Under the influence of magnetic drugs

(Phys.org) -- For more than three decades scientists have been investigating magnetic nanoparticles as a method of drug delivery. Now by combining three metals - iron, gold and platinum - pharmacists at the University of ...

'Copper pump's' potential benefit in cancer treatment

(Phys.org) -- A team of University of California, San Diego researchers has made new discoveries about a copper-transporting protein in the membranes of human cells that drug-discovery scientists can co-opt for the development ...

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Cisplatin

Cisplatin, cisplatinum, or cis-diamminedichloroplatinum(II) (CDDP) (trade names Platinol and Platinol-AQ) is a chemotherapy drug. It is used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas, and germ cell tumors. It was the first member of a class of platinum-containing anti-cancer drugs, which now also includes carboplatin and oxaliplatin. These platinum complexes react in vivo, binding to and causing crosslinking of DNA, which ultimately triggers apoptosis (programmed cell death).

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