Researchers at Baylor College of Medicine and collaborating institutions report in the journal Nature Communications how a mutation in the enzyme SKD3 can cause a form of a genetic disease known as 3-methylglutaconic aciduria ...
Cell & Microbiology
Apr 11, 2023
0
18
The lab of Kathy Gould, Louise B. McGavock Professor and professor of cell and developmental biology, used a multi-disciplinary approach that included structural biology, biochemistry, and molecular biology to investigate ...
Cell & Microbiology
May 9, 2022
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21
We've all suffered from viruses, but did you know that they are also a problem for mushrooms and molds? Mycoviruses are viruses that specifically infect fungi and have the potential to impact ecology, agriculture, food security, ...
Evolution
Dec 21, 2020
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7
Cas9 and Cas12a, two Cas proteins used most in gene-editing, both encompass a RuvC catalytic domain. To understand how the RuvC domain cleaves DNA, it is critical to elucidate the structures of RuvC-containing Cas complexes ...
Molecular & Computational biology
Oct 27, 2020
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4
COVID-19 is caused by a virus known as SARS-CoV-2, which is similar in structure to two other viruses that have caused recent outbreaks: SARS-CoV, which caused an outbreak of SARS in 2003, and MERS-CoV, the cause of a 2012 ...
Biochemistry
Sep 15, 2020
0
76
The Centers for Disease Control and Prevention considers antibiotic resistance one of the most urgent public health threats, one that affects communities worldwide. The ramifications of bacteria's ability to become resistant ...
Cell & Microbiology
Oct 10, 2019
0
43
It was more than 10 years in the making, but when it came to uncovering the secrets of the molecular structure of enzymes, perseverance paid off. By studying and comparing the workhorse cellulose-degrading enzymes of two ...
Biochemistry
Mar 27, 2018
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26
NuA4/Tip60, a complex with diamond ring architecture, is required for regulatory and repairing processes. Prof. CAI Gang and Prof. Jacques Côté's team reports the 4.7 Å structure of the yeast NuA4/TIP60 complex, which ...
Biochemistry
Mar 20, 2018
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19
ATP, the fuel of life, is produced in mitochondria of living cells by a molecular machine, the ATP synthase. We have isolated the machines from four fungal species, compared their stabilities and identified the proteins ...
Biochemistry
Mar 19, 2015
2
7
Purdue researchers have discovered the structure of the enzyme that makes cellulose, a finding that could lead to easier ways of breaking down plant materials to make biofuels and other products and materials.
Biotechnology
Sep 24, 2014
2
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