Systems biology met epigenetics two decades ago and the model did not require computation. It required a common sense approach to nutrient chemical-dependent individual survival and pheromone-controlled reproduction.
This model of systems biology represents the conservation of bottom-up organization and top-down activation via: 1.Nutrient-dependent stress-induced and social stress-induced intracellular changes in the homeostatic balance of microRNA(miRNA) and messenger RNA (mRNA); 2.Intermolecular changes in DNA (genes); 3.Non-random experience-dependent stochastic variations in de novo gene expression for odor receptors; 4.The required gene-cell-tissue-organ-organ system pathway that links sensory input directly to gene activation in neurosecretory cells of the brain; 5.The required reciprocity that links gene expression to behavior that alters gene expression
JVK
Dec 5, 2012