"The beauty of this new technology is it can be used in many immune-related diseases. We simply change the antigen that's delivered."

"Our approach resets the immune system so it no longer attacks myelin but leaves the function of the normal immune system intact."


If those statements both hold up, then this is huge - auto-immune diseases like MS, Type-1 diabetes, arthritis, etc. could be cured.
It is also likely that it could be used to prevent rejection of transplanted organs.

My grandpa's mental state was great for his age until his immune system up and attacked his brain. I think he's on steroids now or something, he can at least make sense when he talks, but.. yeah.

My mom is gluten intolerant. If I understand correctly, this would help there too. But just *think*.. we're on the brink of a developed world without autoimmune disease, at the same time pot is being legalized AND bred to not contain THC, and full-genome and exome sequencing is getting faster and cheaper every month.. The face of death is changing. A world where everyone is forever young is a world where everyone is condemned to die suddenly, in their prime. Maybe it's the best way to go. I'm sure not going to turn down 150 or 200 years if it's offered me, but I really can't say if it'd be a good thing for our species..

It's great progress; I hope human trials can start soon. But they may need to delve into alternative nanoparticle compounds. Seriously, you do not want to inject PLG into lactose-intolerant patients.

This is excellent news and I hope this leads to the improvement of many peoples lives.

The main reason I read Physorg is learn about breakthroughs like this. What a rush!
My daughters have terrible asthma attacks. I hope this technology works in humans and becomes available asap.

The main reason I read Physorg is learn about breakthroughs like this. What a rush!
My daughters have terrible asthma attacks. I hope this technology works in humans and becomes available asap.

Why wait? Pycnogenol, an extract from French Maritime Pine bark has shown to be effective against asthma as well as quercitin, a non-citrus bioflavonoid. These are nature's answers to Merck and Eli Lilly. No side effects, either.

In 2010 studied food science post grad at curtin uni in perth, Western Australia. Accessed high end peer reviewed journals on world databases to also study alzheimers, diabetes and parkinsons concluded:-

Most ppl on a western diet are deficient in Copper & likely molybdenum.

200 plus enzymes & proteins that compete *just* for copper, many are involved with fat metabolisation, insulin, immune system signalling & prion moderation ie Strong binding to copper.

Cause of MS has been correlated with Chlamydophila pneumoniae finds a place to survive in/near CSF pm me for video link, it is dissuaded by healthy copper intake. Also trials of a 3 antibiotic regime against the bacteria in MS sufferers have shown improvement some 2 years ago.

Since I have been on a high copper diet in conjunction with zinc (a co antagonist), manganese & magnesium, a major skin ailment from a maggot from Malaysian jungle in 1998 cleared up totally in 3weeks,

http://en.wikiped...n_health

Telekinetic shared an interesting tidbit
..Pycnogenol, an extract from French Maritime Pine bark has shown to be effective against asthma as well as quercitin, a non-citrus bioflavonoid..
In relation to this is the use of various barka as flavourings for soups and casseroles in Britain for hundreds of years until late 1800's. Had anti-inflammatory properties, I understand they may have been salicylates. The same effect might be achieved by 100mg aspirin a day.

Please, re my last message, always check with a doctor, in a small proportion of ppl aspirin can cause stomach bleeds and make sure you don't have Wilson's disease re inappropriate metabolism re copper...

btw: My own doctor was under impression we can get enough copper from water pipes. Not true as within 3 months new pipes get a bio-film and/or silicates preventing copper leaching into water and the perception re copper being toxic is flawed for anything less than 10mg/day, most people hardly get 300 micrograms/day !

It's great progress; I hope human trials can start soon. But they may need to delve into alternative nanoparticle compounds. Seriously, you do not want to inject PLG into lactose-intolerant patients.

Lactose intolerance is not an immune response. It is simply a lack of enzyme that breaks down lactose in the stomach and therefore it is instead broken down by bacteria in the lower intestines (with all the accompanying symptoms). The enzyme can be ingested prior to any such treatment. But I really doubt that it will be needed since this drug will be in the blood stream and not in the digestion system.

@Telekinetic. Thanks for the recommendation for quercitin and pycnogenol. Both of them are available for a reasonable price from my supplement provider. (It's a good thing they're not too expensive, because my HMO won't pay a nickel toward non-pharmaceuticals.)

Looks like a pretty big deal, but I've seen too many animal studies that didn't translate to humans - so I'll just wait and see until the clinical studies are carried out (at least until they've passed phase II). Then I'll cheer for this.

The biodegradeable part of the nanoparticles is particularly important. Don't want nanoparticles accumulating in the liver/kidney until they pack it in.

antialias_physorg offered observation
Looks like a pretty big deal, but I've seen too many animal studies that didn't translate to humans..
Indeed, the complexities of biochemistry.

Few yrs back with transgenic mice selected for early alzheimers. Feeding Cu organic complexes at high level in diet cleared up Amyloid-Beta42 type plaques *and* reversed their alzheimers 'completely'. Dose was still considerably below LD-50 & not considered toxic, I understand excipient was a powerful anti-emetic but, no human trials. Cu binds well to prions.

Interesting that human liver appears well adapted to high Cu levels, we need ~100ug/(Kg BodyWt)/day.

Most dont realise human fetus, in last trimester, absorbs as much Cu from the mother even to point of making mother dangerously deficient - until the fetus' liver has around 4 times the equivalent adult level of copper !

Mother's milk doesn't deliver much, Cu essential for many enzymes & proteins. Western food has negligible organic bound Cu.

Dose was still considerably below LD-50 & not considered toxic

Stuff is considered toxic WAY below LD-50. The '50' simply means that at that dose 50% of the tested organisms die.

Stuff is considered toxic WAY below LD-50. The '50' simply means that at that dose 50% of the tested organisms die.
Yes ! and the reason I offered is to explore huge variants not the same metric for all poisons. All good microbiologists and food chemists should appreciate the philosophy of Paracelcus Eg.
"All things are poison, and nothing is without poison; only the dose permits something not to be poisonous."

I have read of people randomly taking 100mg/day sporadic copper with only temporary effect of nausea and dizziness, no increased cancer risk and no long term liver damage.

Bile, from the liver, increases its lubricative properties with good consistent copper intakes. Unfortunately many copper salts including the organic variety such as gluconates are emetics.

The blue & slightly bitter mouth fresheners often use copper gluconate. Also chlorophyllin is a copper based food colouring agent produced by some plants, very strong soluble green but not particularly tasty.

The main reason I read Physorg is learn about breakthroughs like this. What a rush!
My daughters have terrible asthma attacks. I hope this technology works in humans and becomes available asap.

I share your hope, but don't get too excited yet. Most things reported here have a fatal flaw in the ointment, like cost, or they only work on mice, or something that the authors don't mention. I am very hopeful of course, but physorg tends to do a LOT of uncritical cheerleading and not as much actual research from what I have seen. I'm not trying to put physorg down, they are fun to read, they just have room for improvement in that area.

could this be aplied to graves disease / leigh disease / melas ?
if you want to test it out, my wife and child have these diseases, we are desparate

could this be aplied to graves disease / leigh disease / melas ?
if you want to test it out, my wife and child have these diseases, we are desparate

So sorry for your plight. Unfortunately, this treatment is a long way off before they can test it on people. Try to find a naturopathic doctor in your area because they treat the system rather than the symptom. I can refer you to an M.D. that might be able to help if you send me a PM.

could this be aplied to graves disease / leigh disease / melas ?
if you want to test it out, my wife and child have these diseases, we are desparate

So sorry for your plight. Unfortunately, this treatment is a long way off before they can test it on people. Try to find a naturopathic doctor in your area because they treat the system rather than the symptom. I can refer you to an M.D. that might be able to help if you send me a PM.


ty for your sympathy, but we live in holland, ill go search for one around here :)

greets :)

Please see my posts re diet and metalloid enzymes, low copper is implicated in failures of various paths of immune system signalling !

Try and find local data re copper/zinc content of your staple foods and get a blood test re serum copper etc...

ty for your sympathy, but we live in holland, ill go search for one around here :)
greets :)